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p53 human
| 产品编号： | 4095362 |
| 规格： | recombinant, expressed in E. coli, buffered aqueous glycerol solution |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.25 |
| General description【一般描述】 | p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain. |
| Application【应用】 | Useful for the study of postranslational modification of p53, or protein-protein interaction studies. |
| Biochem/physiol Actions【生化/生理作用】 | p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer. |
| Physical properties【物理属性】 | GST-tagged, full-length human p53 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥85% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| UniProt accession no.【UniProt登记号】 | P04637 |
| application(s) | genomic analysis |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TP53(7157) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
