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Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit
| 产品编号： | 4095367 |
| 规格： | affinity isolated antibody, lyophilized powder |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD07370454 |
| NACRES | NA.41 |
| General description【一般描述】 | G protein-activated inward rectifier potassium channel 2 (GIRK2) is localized on the plasma membrane. It is expressed majorly in the brain and to some extent in the pancreas. The GIRK2 gene is mapped to human chromosome 21q22.13. Structurally, GIRK2 exists as a tetramer and comprises a transmembrane domain and a cytoplasmic domain. |
| Specificity【特异性】 | Anti-Potassium Channel KIR3.2 (GIRK2) recognizesKIR3.2 (GIRK2). |
| Immunogen【免疫原】 | GST fusion protein with sequence corresponding to residues 374-414 of mouse KIR3.2 (GIRK2). Sequence homology is 40/41, 39/41, and 37/41 residues identical in rat, golden hamster, and human, respectively. |
| Application【应用】 | Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | G protein-activated inward rectifier potassium channel 2,(GIRK2) plays a key role in γ-aminobutyric acid-ergic (GABAergic), dopaminergic, cholinergic, and glutamatergic synapses. It also regulates neuronal excitability. GIRK2 through G protein-coupled receptor stimulation modulates neuronal circuit activity and heart rate in cardiac cells. Deletion of the GIRK2 gene in mice may lead to an anxiety-like phenotype and a depression-resistant behavior. |
| Physical form【外形】 | Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | mouse, rat |
| technique(s) | western blot: 1:200 using rat brain membranes |
| UniProt accession no.【UniProt登记号】 | P48550 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... KCNJ6(3763) mouse ... Kcnj6(16522) rat ... Kcnj6(25743) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
