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06:0 Lyso PA
| 产品编号： | 4095570 |
| 规格： | 1-hexanoyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), powder |
| CAS NO： | 384835-45-4 |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
产品别名
384835-45-4
06:0 Lyso PA
1-hexanoyl-sn-glycero-3-phosphate (ammonium salt); PA(6:0/0:0)
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C9H22NO7P |
| Molecular weight | 287.25 |
| NACRES | NA.25 |
| General description【一般描述】 | Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position. 06:0 Lyso PA/HHGP, belongs to the LPA (lysophosphatidic acid) family. It is a negatively charged single chain lipid. Lysophosphatidic acid (LPA) has a free hydroxyl and phosphate moiety. It is hydrophilic and is not associated with the membrane. It is the major constituent of serum. |
| Application【应用】 | 06:0 Lyso PA (LPA) has been used in the structure-activity relationship (SAR) analysis with G-protein receptor GPR92. It has also been used in lipid assay in the treatment of serum-starved primary mouse embryonic fibroblast cells. 06:0 Lyso PA has been used to study the role of lipid binding to MxiM protein in co‐crystallization experiments. |
| Biochem/physiol Actions【生化/生理作用】 | Lysophosphatidic acid (LPA) participates in several biological functions. LPA stimulates platelet aggregation, chemotaxis, cytoskeleton rearrangement, Ca2+ mobilization and cell proliferation. 06:0 Lyso PA/HHGP possesses a micromolar binding affinity for global regulator of LEE (locus of enterocyte effacement) repressor (GrlR) and for β-lactoglobulin. Lysophosphatidic acid (LPA) is the precursor for the synthesis of phospholipids in eukaryotes and prokaryotes. It acts as an intercellular signaling molecule. Activated platelets produce LPA. It plays a major role in tissue healing and wound regeneration. LPA binds to G-protein coupled receptors. It possesses mitogenic properties. LPA inhibits differentiation of neuroblastoma and myoblast, aids in neurotransmitter release and smooth muscle contraction. It is a potential biomarker for ovarian and gynecological cancers. It is implicated in the initiation of neuropathic pain. |
产品性质
| Assay【测定】 | >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 857119P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O[C@](COP([O-])(O)=O)([H])COC(CCCCC)=O.[NH4+] |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (857119P-25mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
