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VPC 32179 (R)

产品编号:4095786
规格:(R)-phosphoric acid mono-{2-octadec-9-enoylamino-3-[4-(pyridin-2-ylmethoxy)-phenyl]-propyl} ester (ammonium salt), powder
CAS NO:799268-76-1
包装规格:1 MG
产品类别:进口试剂
品牌:Avanti
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40957861 MG1960
产品别名

799268-76-1

VPC 32179 (R)

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C33H54N3O6P
Molecular weight
619.77
NACRES
NA.25
General description【一般描述】
VPC 32179 is devoid of agonist activity at the human LPA2 and LPA3 receptors and behaves as a competitive antagonist at the LPA3 receptor. However, VPC 32179 has been found to have partial agonist activity in a cell migration assay; this is most likely due to activity at the LPA1 receptor.
Application【应用】
VPC 32179 (R) has been used:
  • to examine the roles of lysophosphatidic acid (LPA) receptor subtypes in related adhesion focal tyrosine kinase (RAFTK) activation
  • as a LPA3 receptor antagonist to inhibit LPA-induced protein kinase C (PKC) activity in cultured muscle cells
  • as a LPA1 competitive antagonist to block LPA-induced proliferation of mast cells

Biochem/physiol Actions【生化/生理作用】
VPC 32179 exhibits partial agonist activity in cell migration assay, which is due to the activity at lysophosphatidic acid 1 (LPA1) receptor. It lacks agonist activity at the human LPA2 and LPA3 receptors. VPC 32179 exhibits competitive antagonistic activity at the LPA3 receptor.
产品性质
Assay【测定】
>99% (TLC)
form【形式】
powder
manufacturer/tradename
Avanti Polar Lipids 857350P
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
SMILES string
O=C(CCCCCCC/C=C\CCCCCCCC)N[C@H](CC1=CC=C(OCC2=CC=CC=N2)C=C1)COP(O)([O-])=O.[NH4+]
packaging【包装】
5 mL Amber Glass Screw Cap Vial (857350P-1mg)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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