o-Phenanthroline-CAS 5144-89-8-Calbiochem

C₁₂H₈N₂ · xH₂O

180.21 (anhydrous basis)

MFCD00149973

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a metalloprotease inhibitor. Inhibits glioma invasion in vitro.
A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general matrix metalloproteinase inhibitor. Forms a red chelate with Fe²⁺ that absorbs maximally at 510 nm. Can be used as a photometric reagent for iron.

Primary Target
Metalloprotease inhibitor
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Toxic (F)

Stix, B., et al. 2001. Am. J. Pathol.159, 561.
Bolzan, A.D., et al. 2000. Mutat. Res.447, 221.
Wang, Y., et al. 1999. J. Biol. Chem.274, 33043.
Harayama, T., et al. 1999. Jpn. J. Can. Res.90, 942.
Krane, S.M., et al. 1996. J. Biol. Chem.271, 28509.
Uhm, J.H., et al. 1996. Clin. Exp. Metastasis14, 421.
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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥99% (titration)

solid

Calbiochem^®

OK to freeze
protect from light

white to cream

DMSO: 100 mg/mL
ethanol: 25 mg/mL
water: 3 mg/mL

ambient

10-30℃

1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2

PPQJCISYYXZCAE-UHFFFAOYSA-N

500 mg in Alu drum
Packaged under inert gas

GHS06,GHS09

Danger

H301 - H410

P264 - P270 - P273 - P301 + P310 - P391 - P405

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3