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Anti-PAX6 Antibody
| 产品编号： | 4096113 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PAX6 Antibody
Aniridia type II protein, paired box 6, paired box gene 6, paired box gene 6 (aniridia, keratitis), paired box homeotic gene-6
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans. This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter′s anomaly, both ocular diseases. |
| Specificity【特异性】 | This antibody recognizes the C-Terminus of PAX6. |
| Immunogen【免疫原】 | KLH conjugated followed by PAX6 corresponding to the C-Terminus |
| Application【应用】 | Immunocytochemistry: Working dilutions of 1:50 - 1:1,000 of Anti-Pax6 was used to resolve the protein in chicken spinal cord. Anti-PAX6 Antibody detects level of PAX6 & has been published & validated for use in WB & IC. |
| Quality【质量】 | Routinely evaluated by Western Blot on rat and mouse brain lysates. Western Blot Analysis: 0.5 µg/mL of this lot detected PAX6 on 10 µg of mouse and rat brain lysates. |
| Linkage【联系】 | Replaces: AB5409 |
| Physical form【外形】 | Immunoaffinity purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Mouse and rat brain lysates |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, chicken, mouse |
| should not react with | human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NM_013627 |
| UniProt accession no.【UniProt登记号】 | P26367 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~48 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
