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PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated-Calbiochem
| 产品编号： | 4096121 |
| 规格： | PKA Inhibitor 14-22 Amide is myristoylated at the N-terminus that enhances its cell-permeability. The non-myristoylated version is shown to be a specific inhibitor of PKA (Ki = 36 nM). |
| 包装规格： | 500 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated-Calbiochem
PKI 14-22 Amide, Cell-Permeable, Myristoylated Protein Kinase A Inhibitor Amide 14-22, Cell-Permeable, Myr-GRTGRRNAI-NH2, Protein Kinase A Inhibitor 14-22 Amide, PKA Inhibitor XIII
基本信息
| Empirical Formula【经验(实验)分子式】 | C53H100N20O12 |
| Molecular weight | 1209.49 |
| General description【一般描述】 | Heat-stable protein kinase inhibitor (PKI) peptide sequence (14 - 22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (Ki = 36 nM) of cAMP-dependent protein kinase. Heat-stable protein kinase inhibitor (PKI) peptide sequence (14-22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (Ki = 36 nM) of cAMP-dependent protein kinase (PKA). |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Cell permeable: yes Primary Target cAMP-dependent protein kinase Target Ki: 36 nMf or cAMP-dependent protein kinase Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂ |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Paman, K., et al. 1998. J. Lipid Res. 39, 1091. Rimon, G., and Rubin M. 1998. Biochim. Biophys. Acta 1380, 289. Harris, T.E., et al. 1997. Biochem. Biophys. Res. Commun. 232, 648. Muniz, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14461. Zoukhri, D., et al. 1997. Am. J. Physiol. 272, C263. Eichholtz, T., et al. 1993. J. Biol. Chem.268, 1982. Ward, N.E. and O’Brian, C.A. 1993. Biochemistry32, 11903. Walsh, D.A. and Glass, D.B. 1991. Methods Enzymol. 201, 304. Glass, D.B., et al. 1989. J. Biol. Chem.264, 8802. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| solubility【溶解性】 | water: 1 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 500 μg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
