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IL-4 Receptor human
| 产品编号： | 4096268 |
| 规格： | recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture |
| 包装规格： | 15 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
IL-4 Receptor human
CD124
soluble IL-4 receptor alpha
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized |
| potency【效能】 | ≤5.0 ng/mL ED50 |
| mol wt【分子量】 | 14.9 kDa |
| packaging【包装】 | pkg of 15 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | P24394 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL4R(3566) |
基本信息
| General description【一般描述】 | IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (gc). The type I receptor contains in addition to the gc an IL-4Rα subunit, whereas the type II receptor contains the IL-13Ra. The secreted extracellular domain of IL-4Ra, called sIL-4Ra, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Rα is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-4Rα. |
| Biochem/physiol Actions【生化/生理作用】 | IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (gc). Recombinant human sIL-4Ra is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-4Ra. |
| Sequence【序列】 | GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH |
| Physical form【外形】 | Lyophilized from 1x PBS pH 7.0. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
