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亚叶酸钙
Calcium folinate for system suitability
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4100267 | 1440 |
产品别名
1492-18-8
亚叶酸钙
Calcium folinate for system suitability
Leucovorin calcium salt
5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt
5-Formyl-5,6,7,8-tetrahydropteroyl-
Folinic Acid Calcium Salt Hydrate
Calcium folinate
5-HCO-H4PteGlu
Citrovorum factor calcium salt
5-甲酰基-5,6,7,8-四氢蝶酰基-
叶醛酸钙
亚叶酸 钙盐 水合物
嗜橙菌因子 钙盐
甲酰四氢叶酸 钙盐
5-甲酰基-5,6,7,8-四氢叶酸 钙盐
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H21CaN7O7 · xH2O |
| Molecular weight | 511.50 (anhydrous basis) |
| Beilstein | 5723924 |
| General description【一般描述】 | Calcium folinate, the reduced form of folic acid, finds application in the treatment of methotrexate overdose and in high-dose methotrexate chemotherapy as a chemotherapy protective drug to bring down the latter′s toxicity. When combined with fluorouracil, it is reported to be effective in the management of bowel cancer wherein it acts by inhibiting thymidylate synthase and augmenting the effect of fluorouracil. This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. |
| Application【应用】 | Calcium folinate for system suitability may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography. 叶酸拮抗剂通过结合二氢叶酸还原酶并阻滞叶酸转化为四氢叶酸盐发挥作用，而亚叶酸钙则可抵消叶酸拮抗剂的作用。在医学上，亚叶酸钙在甲氨蝶呤治疗后用于降低甲氨蝶呤的毒性。亚叶酸钙还可用于增强癌症治疗中 5-氟尿嘧啶的细胞毒性效应。 |
| Other Notes【其他说明】 | Sales restrictions may apply. |
产品性质
| biological source【生物来源】 | synthetic |
| grade【等级】 | pharmaceutical primary standard |
| agency | EP |
| form【形式】 | solid |
| manufacturer/tradename | EDQM |
| technique(s) | gas chromatography (GC): suitable liquid chromatography (LC): suitable |
| application(s) | pharmaceutical (small molecule) |
| format【格式】 | neat |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13 |
| packaging【包装】 | Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H315 - H317 - H319 - H334 - H335 |
| Precautionary Statements | P261 - P264 - P280 - P280 - P304 + P340 + P312 - P342 + P311 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
