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Anti-RAB8A Antibody
| 产品编号： | 4101999 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-RAB8A Antibody
Ras-related protein Rab-8A, Oncogene c-mel
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Ras-related protein Rab-8A (RAB8A) is one of two Rab8 isoforms, which belong to the superfamily of GTPases. They cycle between an active GTP-bound state, formed from interaction with guanine nucleotide exchange factors (GEFs) such as Rabin8 and GRAB; and an inactive GDP-bound state via interaction with GTPase activating proteins (GAPs) such as TBC1D1. Rab8A activates various effector molecules, which are coupled to intracellular signaling networks that mediate membrane and vesicular trafficking, and actin remodeling. Rab8A is found in the golgi network, perinuclear region, plasma membrane, lamellipodia, and cilia, among other regions. |
| Specificity【特异性】 | This antibody recognizes the C-terminus of RAB8A. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the C-terminus of human RAB8A. Epitope: C-terminus |
| Application【应用】 | Research Category Cell Structure Western Blot Analysis: A representative lot from an independent laboratory detected RAB8A in human cerebellum and brain. Research Sub Category Vesicular Trafficking This Anti-RAB8A Antibody is validated for use in Western Blotting for the detection of RAB8A. |
| Quality【质量】 | Evaluated by Western Blot in serum starved HeLa cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected RAB8A in serum starved HeLa cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Serum starved HeLa cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), bovine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_005361 |
| UniProt accession no.【UniProt登记号】 | P61006 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~24 kDa observed. Uncharacterized bands may be observed at ~110 kDa and ~38 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
