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IL-21 人

IL-21 human
产品编号:4102036
规格:Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
410203610 μG5280
产品别名

IL-21 人

IL-21 human

基本信息
NACRES
NA.32
General description【一般描述】
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjunction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (gc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant human IL-21 is a 15.0 kDa protein consisting of 132 amino acid residues.
Biochem/physiol Actions【生化/生理作用】
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Recombinant human IL-21 is a 15.0 kDa protein consisting of 132 amino acid residues.
Sequence【序列】
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
Physical form【外形】
Lyophilized from 10 mM Sodium Phosphate, pH 7.6.
Reconstitution【重悬】
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20℃ to -80℃.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥98% (HPLC)
≥98% (SDS-PAGE)
form【形式】
lyophilized
mol wt【分子量】
15.0 kDa
packaging【包装】
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities【杂质】
<0.1 EU/μg endotoxin, tested
color【颜色】
white to off-white
UniProt accession no.【UniProt登记号】
Q9HBE4
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... IL21(59067)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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