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IL-8 (77aa) (CXCL8) human
| 产品编号： | 4102041 |
| 规格： | recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture |
| 包装规格： | 25 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
IL-8 (77aa) (CXCL8) human
NAP-1
monocyte-derived neutrophil chemotactic factor (MDNCF)
CXCL8
neutrophil activating factor (NAF)
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Interleukin-8 (IL-8) is a proinflammatory CXC chemokine that can signal through the C-X-C motif chemokine receptors 1 and 2 (CXCR1 and 2). It is also called as C-X-C motif chemokine ligand 8 (CXCL8). IL-8 is secreted by monocytes and endothelial cells. The gene encoding IL-8 is localized on human chromosome 4q13.3. Recombinant human IL-8 (endothelial-derived) is an 8.9kDa protein containing 77 amino acid residues. |
| Application【应用】 | IL-8 (77aa) (CXCL8) human has been used as a G protein-coupled receptor (GPCR) agonist. |
| Biochem/physiol Actions【生化/生理作用】 | Interleukin-8 (IL-8) chemoattracts and activates neutrophils. It is involved in guiding neutrophils and oligodendrocytes to sites of infection. The protein also stimulates angiogenesis and tumor growth. It is also associated with inflammatory diseases. |
| Sequence【序列】 | AVLPRSAKEL RCQCIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE NWVQRVVEKF LKRAENS |
| Physical form【外形】 | Lyophilized with no additives. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | 8.9 kDa |
| packaging【包装】 | pkg of 25 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
| color【颜色】 | white to off-white |
| UniProt accession no.【UniProt登记号】 | P10145 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL8(3576) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
