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产品别名
Anti-Bax (NT) Antibody
BCL2-associated X protein, Bcl-2-like protein 4, apoptosis regulator BAX
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | BAX (BCL2-associated X protein) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAX protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. |
| Specificity【特异性】 | Rat (90%), Mouse (86%). This antibody recognizes BAX. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human BAX at and around the N-terminus. |
| Application【应用】 | Anti-Bax Antibody is an antibody against Bax (N-terminus) for use in WB, IP, IC, IH. Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated BAX from 500 µg of HL60 cell lysate. Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected BAX in colorectal and ductal carcinoma tissue. Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected BAX in MCF7 cells. |
| Quality【质量】 | Evaluated by Western Blot in HL60 cell lysate. Western Blot Analysis: 0.125 µg/ml of this antibody detected BAX on 10 µg of HL60 cell lysate. |
| Linkage【联系】 | Replaces: 06-499 |
| Physical form【外形】 | Format: Purified Protein A purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human |
| species reactivity (predicted by homology) | rhesus monkey (based on 100% sequence homology), feline (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_620119 |
| UniProt accession no.【UniProt登记号】 | Q07815 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... BAX(581) |
产品说明
| Target description【目标描述】 | ~ 21 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
