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Anti-FOXK2 Antibody

产品编号:4102377
规格:serum, from rabbit
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4102377100 μL5010
产品别名

Anti-FOXK2 Antibody

Forkhead box protein K2, Cellular transcription factor ILF-1, FOXK1, Interleukin enhancer-binding factor 1, FOXK2

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Forkhead box protein K2 (UniProt Q01167; also known as FOXK2, Cellular transcription factor ILF-1, Interleukin enhancer-binding factor 1) is encoded by the FOXK2 (also known as ILF, ILF-1, ILF1) gene (Gene ID 3607) in human. FOXK2 is a transcription factor involved in cell proliferation and survival. FOXK1 and FOXK2 belong to the family of Fox transcription factors characterized by the forkhead DNA-binding domains. However, FOXK1 and FOXK2 can be distinguished from other Fox transcription factors by the presence of the forkhead-associated (FHA) domains. FOXK2 interacts with BRCA1-associated protein 1 (BAP1) through the FHA domain in a BAP1 Thr493 phosphorylation-dependent manner. BAP1 in turn recruits HCF-1, thereby forming a ternary complex at the FOXK2 target genes sites, where BAP1 represses FOXK2 target genes expression in a BAP1 DUB activity-dependent manner.
Specificity【特异性】
Expected to react with isoforms 1&2, but not isoform 3.
Immunogen【免疫原】
Epitope: C-terminal
Recombinant protein corresponding to the C-terminal region of human FOXK2.
Application【应用】
Immunoprecipitation Analysis: A representative lot immunoprecipitated FOXK2 in HeLa nuclear extract (Data courtesy of El Bachir Affar, University of Montreal).
Western Blotting Analysis: A representative lot detected FOXK2 in tag-affinity purified BAP1 complex from HeLa cells expressing Flag-HA-tagged wild-type BAP1 or catalytically dead C91S BAP1 mutant (Mashtalir, N., et al. (2014). Mol. Cell. 54(3):392-406).
Research Sub Category
Nuclear Receptors
Research Category
Epigenetics & Nuclear Function
This Anti-FOXK2 Antibody is validated for use in Western Blotting, Immunoprecipitation for the detection of FOXK2 .
Quality【质量】
Evaluated by Western Blotting in HeLa nuclear extract.

Western Blotting Analysis: A 1:500 dilution of this antibody detected FOXK2 in 10 µg of HeLa nuclear extract.
Physical form【外形】
Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
serum
antibody product type
primary antibodies
clone【克隆】
polyclonal
species reactivity
human
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_004505
UniProt accession no.【UniProt登记号】
Q01167
shipped in【运输】
wet ice
Gene Information
human ... FOXK2(3607)
产品说明
Target description【目标描述】
~78 kDa observed. Isoform 1 (69.1 kDa calculated); Isoform 2 (64.3 kDa calculated).
Storage and Stability【储存及稳定性】
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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