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Anti-IRAK-2 Antibody
| 产品编号： | 4102450 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-IRAK-2 Antibody
Interleukin-1 receptor-associated kinase-like 2, IRAK-2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK-2 also mediates activation of NF-κB, which is a pivotal transcription factor mediating inflammatory and immune response. Additionally, IRAK-2 may play an important role in IL-1R and TLR mediated inflammatory response. IRAK-2 is expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human IRAK-2. |
| Application【应用】 | Anti-IRAK-2 Antibody is a highly specific rabbit polyclonal antibody, that targets IRAK2 & has been tested in western blotting, ICC & Immunofluorescence. Research Sub Category Immunological Signaling Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected IRAK-2 in HeLa cells. Immunofluorescence Analysis: 10 µg/mL from a representative lot detected IRAK-2 in HeLa cells. Research Category Inflammation & Immunology |
| Quality【质量】 | Evaluated by Western Blot in HeLa and K562 cell lysates. Western Blot Analysis: 2 µg/mL of this antibody detected IRAK-2 in 15 µg of HeLa and K562 cell lysates. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control HeLa and K562 cell lysates |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable immunofluorescence: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | O43187 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... IRAK2(3656) |
产品说明
| Target description【目标描述】 | ~65 kDa observed. Uncharacterized bands may appear in some lysate(s). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
