您的位置：首页 > 产品中心 > Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody)
Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody)
| 产品编号： | 4102616 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody)
Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, Neuregulin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, HRG, Neu differentiation factor, Sensory and motor neuron-der
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Neuregulin isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9). Neuregulin Type I/II serve as direct ligands for ERBB3 and ERBB4 tyrosine kinase receptors that regulate development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Type I isoforms are the predominant forms expressed in the endocardium. Type II is the major form in skeletal muscle cells, and is expressed in the spinal cord, brain, adult heart, placenta, lung, liver, kidney, and pancreas. Neuregulin-HBD refers to the heparin binding domain of Type I/II Neuregulin. |
| Specificity【特异性】 | This antibody is expected to cross-react to all Alpha and Beta isoforms (Alpha1A, Alpha2B, Alpha3; and Beta1/1A, Beta2, Beta3), also known as Type I. |
| Immunogen【免疫原】 | Epitope: Extracellular domain GST-tagged recombinant protein corresponding to the extracellular domain of human Pro-neuregulin-1, membrane-bound isoform (NRG1). |
| Application【应用】 | Research Category Cell Structure Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pro-neuregulin-1, membrane-bound isoform (NRG1) in human cardiac myocytes and human cerebellum tissue. This Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody) is validated for use in Western Blotting and Immunohistochemistry for the detection of Pro-neuregulin-1, membrane-bound isoform (NRG1). Research Sub Category Adhesion (CAMs) |
| Quality【质量】 | Evaluated by Western Blotting in PC3 cell lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pro-neuregulin-1, membrane-bound isoform (NRG1) in 10 µg of PC3 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | chimpanzee (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001153467 |
| UniProt accession no.【UniProt登记号】 | Q02297 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... NRG1(3084) |
产品说明
| Target description【目标描述】 | ~110 and ~58 kDa observed. May detect multiple isoforms (Alpha1A, Alpha2B, Alpha3; and Beta1/1A, Beta2, Beta3). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
