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C1 Inhibitor human
产品编号: | 4102735 |
规格: | recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC) |
包装规格: | 200 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
C1 Inhibitor human
C1inh
Plasma protease C1 inhibitor
Serpin G1
基本信息
NACRES | NA.32 |
General description【一般描述】 | Plasma protease C1 inhibitor is a member of the serpin family of structurally related proteins. Recombinant Human C1 inhibitor is a highly glycosylated glycoprotein containing 478 amino acid residues (52.8kDa), corresponding to amino acids 23-500 of the C1 inhibitor precursor, and is fully functional in its ability to inhibit the C1 complex. Glycosylated C1 inhibitor migrates at an apparent molecular weight of approximately 80-90kDa by SDS PAGE analysis under reducing conditions. |
Biochem/physiol Actions【生化/生理作用】 | Plasma protease C1 inhibitor is the primary regulator of the immune complement system. C1 inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1 inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa. Deficiencies in C1 inhibitor are the primary cause of hereditary angioedema (HAE, hereditary angioneurotic edema), a disease characterized by edema in the respiratory and gastrointestinal tracts. In certain clinical situations, the direct administration of C1 inhibitor can be used to treat HAE and certain other conditions. |
Physical form【外形】 | Lyophilized from 10mM Sodium Phosphate, pH 7.5. |
Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in CHO cells |
Assay【测定】 | ≥95% (HPLC) ≥95% (SDS-PAGE) |
form【形式】 | lyophilized |
potency【效能】 | ≤2.6 nM IC50 |
mol wt【分子量】 | 52.8 kDa |
packaging【包装】 | pkg of 200 μg |
impurities【杂质】 | endotoxin, tested |
UniProt accession no.【UniProt登记号】 | P05155 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... SERPING1(710) |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |