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MMP-2 human
产品编号: | 4103057 |
规格: | recombinant, ≥1,000 pmol/min/μg, expressed in HEK 293 cells |
包装规格: | 50 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
MMP-2 human
72 kDa gelatinase
MMP-2
Matrix metalloproteinase-2
Gelatinase A
TBE-1
产品性质
recombinant【重组】 | expressed in HEK 293 cells |
Quality Level【质量水平】 | 200 |
Specific Activity | ≥1000 pmol/min-μg |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
基本信息
General description【一般描述】 | Matrix Metalloproteinase-2 (MMP-2) is a member of the matrix metalloproteinase (MMP) family of proteins. MMPs participate in the breakdown of extracellular matrix in normal physiological processes like embryonic development, reproduction, and tissue remodeling, as well as in disease processes such as arthritis and metastasis. MMP-2 cleaves many substrates, including extracellular matrix components (collagens, fibronectin, and elastin), soluble metabolic mediators (e.g., apolipoproteins), secreted and extracellular matrix-anchored growth factors, and cytokines. Along with MMP-9, MMP-2 is involved many pathophysiological processes, including leukocyte migration from the circulation into the tissue during inflammation, Chagas′ Cardiomyopathy, heart failure and chronic kidney disease. MMP-2 thus may be regarded as a potential therapeutic target. As with most MMPs, MMP-2 is secreted as an inactive pro-protein, which becomes activated when cleaved by extracellular proteinases. This product is not pre-activated, and may be activated by APMA or otherwise This product is expressed in human HEK 293 cells as a glycoprotein with a calculated molecular mass of 72 kDa (amino acids 110-660). The DTT-reduced protein migrates as a 75-80 kDa polypeptide on SDS-PAGE because of glycosylation. This protein is produced in human cells, without the use of serum. The human cells expression system allows human like glycosylation and folding, and often supports higher specific activity of the protein. This recombinant protein is expressed without artificial tags. |
Features and Benefits【特点和优势】 |
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Physical form【外形】 | This product is supplied as a 0.22 μm-filtered solution, containing 20 mM Trizma®, pH 7.5, containing 8 mM CaCl2, 119 mM NaCl, 20% Glycerol, and 0.05% Brij® 35. |
Legal Information【法律信息】 | Brij is a registered trademark of Croda International PLC Trizma is a registered trademark of sigma-aldrich Co. LLC |
产品说明
Storage and Stability【储存及稳定性】 | Store the product at –70 ℃. The product retains its activity for at least 2 years as supplied. After initial thawing, it is recommended to store the protein in working aliquots at –70 ℃. |
Disclaimer【免责声明】 | This product is for R&D use only. Not for drug, household, or other uses. Please consult the Safety Data Sheet for information regarding hazards and safe handling practices |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |