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MMP-3 人

MMP-3 human
产品编号:4103059
规格:recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
CAS NO:79955-99-0
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
410305910 μG4690
产品别名

79955-99-0

MMP-3 人

MMP-3 human

Stromelysin-1

EC 3

Matrix metalloproteinase-3

基本信息
MDL number
MFCD00282364
NACRES
NA.32
General description【一般描述】
The gene JE is an early growth response gene that was first identified in mouse 3T3 cells. The gene is mapped to mouse chromosome 11. It encodes a member of the CC subfamily, the members of which contain characteristic two adjacent cysteine residues.
Active MMP-3 catalytic domain from human cDNA, expressed in E. coli and purified using proprietary technologies. The active MMP-3 is very useful in studying enzyme kinetics, cleave target substrates, and screen for inhibitors.
Application【应用】
MMP-3 human has been used to develop a simple and sensitive electrogenerated chemiluminescence (electrochemiluminescence (ECL)) peptide-based bioassay for the detection of matrix metalloproteinases releasing from living cells.
MCP-1 has been used to induce chemotaxis in mice macrophages.
Biochem/physiol Actions【生化/生理作用】
The gene JE, also referred to as MCP-1 (monocyte chemoattractant protein-1), encodes a secreted chemokine that functions as a chemoattractant for monocytes and may activate their anti-tumor properties. This protein may serve as a potential therapeutic anticancer agent.
Matrix metallopeptidase 3 (MMP3) has a broad substrate specificity and is capable of degrading fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. It participates in wound repair, progression of atherosclerosis, tissue remodeling and tumor initiation. MMP3 variants can be associated with hypertrophy of interventricular septum or hypertrophic cardiomyopathy.
Physical form【外形】
Lyophilized powder.
Reconstitution【重悬】
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile PBS to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥95% (HPLC)
≥95% (SDS-PAGE)
form【形式】
lyophilized
mol wt【分子量】
~19.5 kDa
packaging【包装】
pkg of 10 μg
technique(s)
western blot (chemiluminescent): suitable
impurities【杂质】
endotoxin, tested
NCBI accession no.【NCBI登记号】
P08254
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... MMP3(4314)
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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