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阿米替林代谢物，(±)-E-10-羟基化-
(E)-10-Hydroxy amitriptyline
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4103434 | 10 MG | 6510 |
产品别名
64520-05-4
阿米替林代谢物，(±)-E-10-羟基化-
(E)-10-Hydroxy amitriptyline
Amitriptyline metabolite, (±)-E-10-hydroxylated-
(±)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol
Amitriptyline
(±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[a,d]环庚烯-10-醇
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H23NO |
| Molecular weight | 293.40 |
| MDL number | MFCD00069200 |
| General description【一般描述】 | (E)-10-Hydroxy amitriptyline is a metabolite of Amitriptyline (brand name Elavil), a FDA-approved oral medicine for the treatment of major depressive and anxiety disorders, attention deficit hyperactivity disorder (ADHD), bipolar disorder, as well as migraines and neuropathic pain (fibromyalgia & postherpetic neuralgiapain). Amitriptyline acts mainly on the serotonin transporter (SERT) and moderately on the norepinephrine transporter (NET). Amitriptyline is metabolised by cytochrome P450 enzymes (demethylation by CYP2C19 & CYP3A4) in the liver to Nortriptyline, which also acts as a noradrenaline reuptake inhibitor and thereby potentiates the antidepressant effects of amitriptyline. Amitriptyline and Nortriptyline are subject to metabolisation by hydroxylation (by CYP2D6) and n-oxidation. |
| Application【应用】 | Metabolomics research |
| Biochem/physiol Actions【生化/生理作用】 | 阿米替林代谢物，三环抗抑郁剂；色谱标准品。 |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| technique(s) | HPLC: suitable |
| color【颜色】 | white to yellow |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13 |
| InChI | 1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+ |
| InChI key | GHWBJXOKAFHZAI-SFQUDFHCSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
