Anti- STING, clone 41 Antibody

32160702

NA.41

STING, also known as mSTING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and encoded by the gene Tmem 173/Eris/Mita/Mpys/Sting, is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferons. STING acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol. Upon binding STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. STING also mediates cell death signaling via the activation of the ERK pathway. STING is found in multiple intracellular locations including the endoplasmic reticulum, plasma cell membrane, mitochondrion outer membrane, and perinuclear regions. STING is expressed in the B-cell lineage both immature and mature B cells but not plasma cells. Mutations in STING cause defects in innate immunity and compromised immune health.

Recombinant protein corresponding to the cytoplasmic domain of mouse STING.

This Anti- STING, clone 41 Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of STING.
Flow Cytometry Analysis: 2 µg of this antibody detected STING in mouse splenocyte cells.

Evaluated by Western Blotting in RAW264.7 cell lysate.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected STING in 10 µg of RAW264.7 cell lysate.

Purified by Ion-Exchange Chromatography
Format: Purified

100

rat

purified antibody

primary antibodies

41, monoclonal

mouse

0.5 mg/mL

flow cytometry: suitable
western blot: suitable

IgMκ

NP_082537

Q3TBT3

wet ice

~42 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~38 kDa and ~48 kDa

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12 - Non Combustible Liquids

WGK 2