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Anti-acetyl Histone H3 (Lys9), Alexa Fluor® 488 Conjugate Antibody
产品别名
Anti-acetyl Histone H3 (Lys9), Alexa Fluor® 488 Conjugate Antibody
Histone H3.1t, H3/t, H3t, H3/g, acetyl Histone H3 (Lys9)
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely by acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1α. The enzymes responsible for H3K9 trimethylation are SUV39H1 and SUV39H2. |
| Immunogen【免疫原】 | Linear peptide corresponding to acetyl Histone H3 (Lys9). |
| Application【应用】 | This Anti-acetyl Histone H3 (Lys9) is validated for use in Immunocytochemistry for the detection of acetyl Histone H3 (Lys9). Research Category Epigenetics & Nuclear Function Research Sub Category Nuclear Receptors |
| Quality【质量】 | Evaluated by Immunocytochemistry in A431 cells. Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected acetyl Histone H3 (Lys9) in A431 cells. ABE18-AF488 is derived from its parent antibody ABE18. Alexa Fluor® is a registered trademark of Life Technologies |
| Physical form【外形】 | Purified rabbit IgG in PBS containing 15 mg/mL BSA and 0.1% Sodium Azide. Affinity purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
| Legal Information【法律信息】 | ALEXA FLUOR is a registered trademark of Life Technologies |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | ALEXA FLUOR® 488 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human |
| species reactivity (predicted by homology) | chicken (based on 100% sequence homology), mouse (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003484 |
| UniProt accession no.【UniProt登记号】 | Q16695 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 17 kDa observed. Molecular weight was observed with parent ABE18. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
