Anti-Amyloid, β 1-40, aβ Antibody

32160702

NA.41

Amyloid β 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid β 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer’s disease. Previous studies have reported that expression of amyloid β 1-40 increases in Alzheimer’s disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation.

This antibody recognizes the P3(40) peptide of Amyloid, β 1-40.

KLH-conjugated linear peptide corresponding to the P3(40) peptide of human Amyloid, B 1-40.
Epitope: P3(40) peptide

Research Category
Neuroscience
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Amyloid, B 1-40 in human Alzheimer′s diseased brain tissue.

ELISA: A representative lot detected Amyloid, B 1-40 in ELISA (Direct).
Research Sub Category
Neurodegenerative Diseases
Anti-Amyloid, β 1-40, aβ Antibody is an antibody against Amyloid, β 1-40, aβ for use in Western Blotting, IHC(P), ELISA.

Evaluated by Western Blot in human Alzheimer brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Amyloid, B 1-40 on 10 µg of human Alzheimer brain tissue lysate.

Replaces: AB5737

Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

Control
Human Alzhiemer brain tissue lysate

rabbit

100

affinity isolated antibody

primary antibodies

polyclonal

affinity chromatography

human

mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology)

ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

NP_001129601

P05067

wet ice

human ... APP(351)

~4 kDa observed. An uncharacterized band appears at ~19 kDa in some lysates.

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 1