您的位置：首页 > 产品中心 > Anti-Axin2, clone cond4-1D5 Antibody
Anti-Axin2, clone cond4-1D5 Antibody
产品别名
Anti-Axin2, clone cond4-1D5 Antibody
Axin-2, Axin-like protein, Axil, Conductin
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Axin-2, or Axis inhibition protein 2, is an inhibitor of the Wnt signaling pathway that down-regulates beta-catenin and APC through phosphorylation. Axin-2 abnormalities are linked to defective mismatch repair and have been found to be involved in colorectal cancer (CRC) and oligodontia-colorectal cancer syndrome (ODCRCS). Axin-2 can be found in brain and lymphoblast tissues. |
| Specificity【特异性】 | This monoclonal antibody recognizes both endogeneous and overexpressed Axin2 and does not cross-react with Axin1 |
| Immunogen【免疫原】 | Linear peptide corresponding to Human Axin 2. |
| Application【应用】 | Immunocytochemistry Analysis: 20 μg/mL of this antibody from a representative lot detected Axin2 in HeLa, HEK293 and NIH-3T3 cells. Western Blotting Analysis: A representative lot of this antibody detected Axin2 in SW 480 cell lines Research Sub Category General Post-translation Modification This Anti-Axin2, clone cond4-1D5 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of Axin2. Research Category Signaling Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Western Blotting in HCT116 cell lysate. Western Blotting Analysis: 1 μg/mL of this antibody detected Axin2 in 10 µg of HCT116 cell lysate. |
| Physical form【外形】 | Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | rat |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | cond4-1D5, monoclonal |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG2aκ |
| NCBI accession no.【NCBI登记号】 | NP_004646 |
| UniProt accession no.【UniProt登记号】 | Q9Y2T1 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 95 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
