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Anti-CD39 Antibody, clone 5E12
产品别名
Anti-CD39 Antibody, clone 5E12
Ectonucleoside triphosphate diphosphohydrolase 1, NTPDase 1, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, Ecto-apyrase, Lymphoid cell activation antigen, CD39
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | CD39 (EC 3.6.1.5; also known as Ecto-apyrase, Ecto-ATPase 1, Ecto-ATPDase1 , Ecto-ATP diphosphohydrolase 1, Ectonucleoside triphosphate diphosphohydrolase 1, Lymphoid cell activation antigen, NTPDase 1) is encoded by the Entpd1 or Cd39 gene (Entrez Gene ID 12495) in murine species. CD39 is a cell surface nucleotide-metabolizing enzyme that hydrolyzes extracellular purine NTP and NDP. E. coli infection is reported to induce CD39 promoter activity in macrophages, resulting in an upregulated CD39 expression during sepsis in mice, while CD39 knockdown increases mortality among mice with polymicrobial sepsis (PMID 25318479). Anti-CD39, clone 5E12 binds the murine CD39 (P55772) extracellular domain and is demonstrated to selectively stain murine macroglia by flow cytometry (PMID 22863620). |
| Immunogen【免疫原】 | Epitope: extracellular domain Whole cells with surface CD39. |
| Application【应用】 | Research Category Neuroscience Flow Cytometry Analysis: A representative lot detected CD39 in CD11b+ cells (Butovsky, O., et al. (2012). J. Clin. Invest. 122(9):3063-3087). Anti-CD39 Antibody, clone 5E12 is an antibody against CD39 for use in Flow Cytometry. Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Flow Cytometry in CD11b+ mouse splenocytes. Flow Cytometry Analysis: Various dilutions of this antibody detected CD39 in CD11b+ mouse splenocytes. |
| Physical form【外形】 | Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | rat |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 5E12, monoclonal |
| species reactivity | mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | flow cytometry: suitable |
| isotype【同位素/亚型】 | IgG2aκ |
| NCBI accession no.【NCBI登记号】 | NP_033978 |
| UniProt accession no.【UniProt登记号】 | P55772 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 70-100 kDa calculated |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10-13 - German Storage Class 10 to 13 |
