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产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody product type | primary antibodies |
| clone【克隆】 | monoclonal |
| form【形式】 | liquid |
| species reactivity | rat, human |
| concentration【浓度】 | 0.55 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt accession no.【UniProt登记号】 | P08473 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MME(4311) |
基本信息
| General description【一般描述】 | This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008] |
| Immunogen【免疫原】 | A synthesized peptide derived from human CD10/MME |
| Physical form【外形】 | Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
