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Anti-FANCJ/BACH1 Antibody, clone 2G7
产品别名
Anti-FANCJ/BACH1 Antibody, clone 2G7
Fanconi anemia group J protein, Protein FACJ, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1, BRCA1-interacting protein 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Bach1 and Bach2 constitute a subfamily of the basic region-leucine zipper family. Bach proteins form heterodimers with small Maf proteins, bind to the Maf recognition element (MARE) and repress target gene expression. Transcription regulator protein BACH2 mediates early B cell differentiation and is specifically expressed in pro and mature B-cells. This protein plays an important role in both the immunoglobulin class switch, oncogene-induced senescence, and somatic hypermutation. |
| Immunogen【免疫原】 | Linear peptide corresponding to the C-terminus of human FANCJ/BACH1. Epitope: C-terminus |
| Application【应用】 | This Anti-FANCJ/BACH1 Antibody, clone 2G7 is validated for use in western blotting, ICC & IP for the detection of FANCJ/BACH1. Research Sub Category Apoptosis - Additional Research Category Apoptosis & Cancer Immunocytochemistry Analysis: A representative lot from an independent laboratory detected FANCJ/BACH1 in MCF-7 cells (Cantor, S. B., et al. (2001). Cell. 105(1):149-160.). Western Blotting Analysis: A representative lot from an independent laboratory detected FANCJ/BACH1 in transfected FA-J cell lysate (Xie, J., et al. (2010). Oncogene. 29(17):2499-2508.). Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated FANCJ/BACH1 from MCF-7 cell lysate, prior to detecting the immunoprecipitated sample in Western Blot (Cantor, S. B., et al. (2001). Cell. 105(1):149-160.). |
| Quality【质量】 | Evaluated by Western Blotting in MCF-7 cell lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected FANCJ/BACH1 in 10 µg of MCF-7 cell lysate. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 2G7, monoclonal |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_114432 |
| UniProt accession no.【UniProt登记号】 | Q9BX63 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... BRIP1(83990) |
产品说明
| Target description【目标描述】 | ~140 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
