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Anti-Forkhead box protein K2 (FOXK2)

产品编号:4107886
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4107886100 μG4510
产品别名

Anti-Forkhead box protein K2 (FOXK2)

Forkhead box protein K2, Cellular transcription factor ILF-1, FOXK1, Interleukin enhancer-binding factor 1

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Forkhead box protein K2 (UniProt: Q01167; also known as Cellular transcription factor ILF-1, FOXK1, Interleukin enhancer-binding factor 1) is encoded by the FOXK2 (also known as ILF, ILF1) gene (Gene ID: 3607) in human. Forkhead box protein K2 is a transcriptional regulator that recognizes the core sequence 5′-TAAACA-3′. It is expressed in both lymphoid and non-lymphoid cells. Three isoforms of Forkhead box protein K2 have been reported that are produced by alternative splicing. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Forkhead box protein K2 is reported to positively regulate WNT/beta-catenin signaling by translocating DVL proteins into the nucleus. Higher levels of FOXK1 and FOXK2 are reported in human colorectal cancers and correlate with DVL nuclear localization. Both FOXK1 and FOXK2 proteins are shown to act as transcriptional repressors of autophagy in muscle cells and fibroblasts. They specifically recruit Sin3A HDAC complexes to restrict acetylation of histone H4 and expression of critical autophagy genes. The loss of FOXK1 and FOXK2 proteins results in the upregulation of several genes controlling the initiation and nucleation of autophagosome formation. (Ref.: Bowman, CJ., et al. (2014). Nat. Cell Biol. 16(12); 1202-1214).
Specificity【特异性】
This rabbit polyclonal antibody detects Forkhead box protein K2 in human cells. It targets an epitope within 17 amino acids from the C-terminal half.
Immunogen【免疫原】
Epitope: C-terminus
KLH-conjugated linear peptide corresponding to 17 amino acids from the C-terminal half of human Forkhead box protein K2.
Application【应用】
Western Blotting Analysis: 2 µg/mL from a representative lot detected Forkhead box protein K2 (FOXK2) in HeLa cell lysate.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Forkhead box protein K2 (FOXK2) in human cerebral cortex, human prostate cancer, and human pancreatic cancer tissues.

Research Category
Epigenetics & Nuclear Function
Anti-Forkhead box protein K2 (FOXK2), Cat. No. ABE1323, is a highly specific rabbit polyclonal antibody that targets Forkhead box protein K2 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Quality【质量】
Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected Forkhead box protein K2 (FOXK2) in HEK293 cell lysate.
Physical form【外形】
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Affinity Purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype【同位素/亚型】
IgG
NCBI accession no.【NCBI登记号】
NP_004505.2
UniProt accession no.【UniProt登记号】
Q01167
shipped in【运输】
ambient
Gene Information
human ... FOXK2(3607)
产品说明
Target description【目标描述】
~69 kDa observed; 69.06 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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