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Anti-FOXL2 Antibody
| 产品编号： | 4107906 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-FOXL2 Antibody
Forkhead box protein L2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Forkhead box protein L2 (FOXL2) is a fork-head transcription factor that is expressed in developing gonad and in granulosa cells of the mature ovary. It plays a role in repressing the development of testis, and facilitating the differentiation and maintenance of the ovary. Mutations in the FOXL2 gene result in blepharophimosis ptosis epicanthus inversus (BPES) syndrome, which is characterized by craniofacial defects and premature ovarian failure. FOXL2 has also been implicated in the development of ovarian granulosa cell tumors. |
| Specificity【特异性】 | Other homologies: Chicken (77% sequence homology). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human FOXL2. |
| Application【应用】 | This Anti-FOXL2 Antibody is validated for use in Western Blotting for the detection of FOXL2. Research Category Epigenetics & Nuclear Function Research Sub Category Chromatin Biology |
| Quality【质量】 | Evaluated by Western Blot in human pituitary tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected FOXL2 in 10 µg of human pituitary tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Human pituitary |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), rabbit (based on 100% sequence homology), bovine (based on 100% sequence homology), porcine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_075555 |
| UniProt accession no.【UniProt登记号】 | P58012 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~50 kDa observed. An uncharacterized band may appear at ~25 kDa in some lysates. The calculated molecular weight is 39 kDa, however FOXL2 has been shown as a ~50 kDa band in western blots (Marongiu, M., et al. (2010). PLOS One. 5(3):1-9). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
