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Anti-GCM2 Antibody, clone 8A10.1
产品别名
Anti-GCM2 Antibody, clone 8A10.1
hGCMb, Chorion-specific transcription factor GCMb, GCM2, GCM 2, GCM-2, GCM motif protein 2, Glial cells missing homolog 2
基本信息
| eCl@ss | 32160702 |
| General description【一般描述】 | GCM2 is a nuclear protein that is involved in transcription regulation of many genes including ones important in parathyroid metabolism and development. Glial cells missing homolog 2 or GCM2 is expressed predominately in the pharyngeal pouches and, at later stages, in the developing and mature parathyroid glands. In humans, loss of GCM2 function, either through recessive apomorphic mutations or dominant inhibitor mutations in the human GCM2 gene, leads to isolated hypoparathyroidism. GCM2 expression is continued in the adult parathyroid at high levels and appears to be important in calcium sensing and calcium receptor expression in adult parathyroid cells. |
| Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to Human GCM2. |
| Application【应用】 | Research Category Neuroscience Research Sub Category Developmental Neuroscience This Anti-GCM2 Antibody, clone 8A10.1 is validated for use in Western Blotting for the detection of GCM2. |
| Quality【质量】 | Evaluated by Western Blotting in SH-SY5Y cell lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected GCM2 in 10 µg of SH-SY5Y cell lysate. |
| Physical form【外形】 | Purified by Ion-Exchange Chromatography Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. Format: Purified |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 8A10.1, monoclonal |
| species reactivity | human |
| concentration【浓度】 | 0.5 mg/mL |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgMκ |
| NCBI accession no.【NCBI登记号】 | NP_004743 |
| UniProt accession no.【UniProt登记号】 | O75603 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 58 kDa observed. An uncharacterized band appears at ~110 kDa in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
