Anti-GRIM-19, clone 1A8 Antibody

32160702

NA.41

GRIM-19, also known as NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, Cell death regulatory protein GRIM-19, Complex I-B16.6, CI-B16.6, Gene associated with retinoic and interferon-induced mortality 19 protein, Gene associated with retinoic and IFN-induced mortality 19 protein, NADH-ubiquinone oxidoreductase B16. GRIM-19 6 subunit, is encoded by the gene name NDUFA13, GRIM19, CDA016, CGI-39. GRIM-19 is accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I NADH dehydrogenase plays an important role in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. GRIM-19 is also suggested to be involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Additionally, GRIM-19 may play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.GRIM-19 is expressed widely, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In the intestinal mucosa, GRIM-19 is down-regulated in areas involved in Crohn disease and ulcerative colitis. Mutations in GRIM-19 have been associated with Hurthle cell thyroid carcinoma (HCTC), a rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers.

Recombinant protein corresponding to human GRIM-19.

Anti-GRIM-19, clone 1A8 | MABC590 is an antibody against GRIM-19 for use in Western Blotting, Immunoprecipitation, Immunocytochemistry.
Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: A representative lot detected GRIM-19 in MCF-7 and RAW264.7 cell lysate (Hu, J., et al. (2002). J. Interferon & Cytokine Research. 22:1017-1026).
Immunoprecipitation Analysis: A representative lot immunoprecipitated GRIM-19 in MCF-7 cell lysate (Hu, J., et al. (2002). J. Interferon & Cytokine Research. 22:1017-1026).
Immunocytochemistry Analysis: A representative lot detected GRIM-19 in MCF-7 cells (Hu, J., et al. (2002). J. Interferon & Cytokine Research. 22:1017-1026).
Research Category
Apoptosis & Cancer

Evaluated by Western Blotting in MCF-7 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected GRIM-19 in 10 µg of MCF-7 cell lysate.

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

Concentration: Please refer to lot specific datasheet.

100

mouse

purified immunoglobulin

primary antibodies

1A8, monoclonal

mouse, human

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

IgG2bκ

NP_057049

Q9P0J0

wet ice

~16 kDa observed

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 1