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Anti-LAR/PTPRF Antibody, clone N165/38

产品编号:4109678
规格:clone N165/38, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4109678100 μG5850
产品别名

Anti-LAR/PTPRF Antibody, clone N165/38

Receptor-type tyrosine-protein phosphatase F, Leukocyte common antigen related, LAR

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Receptor-linked protein-tyrosine phosphatases (RPTPs) are signaling proteins that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. Leukocyte common antigen receptor protein tyrosine phosphatase (LAR/PTPRF), a negative regulator of several receptor tyrosine kinases, is present in high concentrations in mature synapses and is considered to be important for the development and maintenance of excitatory synapses in hippocampal neurons. Disruption of LAR function is shown to result in loss of excitatory synapses, diminution in surface AMPA receptors, and impairment of dendritic targeting of the cadherin–beta-catenin complex. LAR is also present in neurons expressing TrkB where it participates in survival of neurons and the neurite outgrowth. Increased expression of LAR in insulin-responsive tissues has also been associated with obesity and insulin resistance.
Specificity【特异性】
Other Homologies: Mouse (97% sequence homology).
This antibody does not cross-react with PTPRD and PTPRS (Prof. J. Trimmer, University of California, Davis.).
Immunogen【免疫原】
Recombinant protein corresponding to human LAR/PTPRF.
Application【应用】
Research Sub Category
Synapse & Synaptic Biology
Anti-LAR/PTPRF Antibody, clone N165/38 is a highly specific mouse monoclonal antibody & that targets LAR & has been tested in western blotting.
Research Category
Neuroscience
Quality【质量】
Evaluated by Western Blotting in rat brain membrane tissue.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected LAR/PTPRF in 10 µg of rat brain membrane tissue.
Physical form【外形】
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Analysis Note【分析说明】
Control
Rat brain membrane tissue
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
N165/38, monoclonal
species reactivity
rat
technique(s)
western blot: suitable
isotype【同位素/亚型】
IgG2aκ
NCBI accession no.【NCBI登记号】
NP_002831
UniProt accession no.【UniProt登记号】
P10586
shipped in【运输】
wet ice
Gene Information
human ... PTPRF(5792)
产品说明
Target description【目标描述】
~78 kDa observed. The full length protein is 210 kDa; however, it runs lower in Western Blotting due to proteolysis into P-subunit containing transmembrane and intracellular domains (Prof. J. Trimmer, University of California, Davis).
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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