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产品别名
Anti-LGI1 Antibody
Leucine-rich, glioma inactivated 1, epitempin, EPT
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are very similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. |
| Specificity【特异性】 | This antibody recognizes only Isoform 1. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human LGI1. |
| Application【应用】 | Research Category Neuroscience Research Sub Category Developmental Neuroscience Western Blot Analysis: 2 µg/mL from a representative lot detected LGI1 in 10 µg/mL of HEK293 cell lysate. Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected LGI1 in mouse cerebellum and rat cortex tissues. Detect the LGI1 protein using this Anti-LGI1 validated for use in WB & IHC. |
| Quality【质量】 | Evaluated by Western Blot in mouse brain tissue lysate. Western Blot Analysis: 2 µg/mL of this antibody detected LGI1 in 10 µg/mL of mouse brain tissue lysate. |
| Physical form【外形】 | Format: Purified Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Mouse brain tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | rat, mouse, human |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | O95970 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... LGI1(9211) |
产品说明
| Target description【目标描述】 | ~64 kDa observed. Uniprot describes 3 isoforms at ~33 kDa, ~58 kDa, and ~64 kDa An uncharacterized band may appear at ~45 kDa in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
