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Anti-MAP2 Antibody, clone AP20, Biotin Conjugated
| 产品编号： | 4110006 |
| 规格： | clone AP20, from mouse, biotin conjugate |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-MAP2 Antibody, clone AP20, Biotin Conjugated
Microtubule-associated protein 2, MAP-2, MAP2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules (Herzog and Weber, 1978), and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules. |
| Immunogen【免疫原】 | Bovine brain microtubule protein |
| Application【应用】 | Anti-MAP2 Antibody, clone AP20, Biotin Conjugated is an antibody against MAP2 for use in ICC. Immunocytochemistry Analysis: A 1:25 dilution from a representative lot detected MAP2 in rat E18 primary cortex cells. |
| Quality【质量】 | Evaluated by Immunohistochemistry in rat cortex tissue. Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected MAP2 in rat cortex tissue. |
| Physical form【外形】 | Purified mouse monoclonal IgG conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA. Protein G Purified |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | biotin conjugate |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | AP20, monoclonal |
| species reactivity | rat |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), bovine (immunogen homology), human (based on 100% sequence homology), chicken (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable |
| isotype【同位素/亚型】 | IgG |
| UniProt accession no.【UniProt登记号】 | Q0IIA8 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | The unconjugated parent antibody (Cat. No. MAB3418) has an observed molecular weight at ~230 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
