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Anti-Myosin-VI Antibody
| 产品编号： | 4110689 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Myosin-VI Antibody
Myosin-VI, Unconventional myosin-6
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Myosin-VI has been found in the membrane ruffles at the leading edge of the Golgi complex. Myosin-VI moves along the actin in the opposite way of other known myosins to date, toward the minus end. It can exist as a dimer and a monomer and is thought to function as a non-processive motor with a 18nm working stroke. Myosin-VI has also been found in the brain, specifically the synapses. Myosin-VI deficiency (Snell’s waltzer disease) in the hippocampus causes a smaller number of synapses, short dendritic spines and astrogliosis. Myosin-VI may also be important in clathrin-mediated endocytosis of acid-type glutamate receptors. Recent research has implicated myosin-VI in the enrichment of proteins on the surface of axons. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human Myosin-VI. |
| Application【应用】 | Immunocytochemistry analysis: A 1:500 dilution from a representative lot detected Myosin-VI in NIH/3T3 and A431 cells. Research Category Cell Structure Anti-Myosin-VI Antibody detects level of Myosin-VI & has been published & validated for use in WB & IC. Research Sub Category Cytoskeleton |
| Quality【质量】 | Evaluated by Western Blot in MDCK cell lysate. Western Blot Analysis: A 1:1,000 dilution of this antibody detected Myosin-VI in 10 µg of MDCK cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control MDCK cell lysate |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human, canine |
| species reactivity (predicted by homology) | rat (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_004990 |
| UniProt accession no.【UniProt登记号】 | Q9UM54 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... MYO6(4646) |
产品说明
| Target description【目标描述】 | ~150 kDa observed. An uncharacterized band appears at ~55 kDa in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
