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Anti-NDUFS3 Antibody, clone 6H7.1
产品别名
Anti-NDUFS3 Antibody, clone 6H7.1
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial, Complex I-30kD, CI-30kD, NADH-ubiquinone oxidoreductase 30 kDa subunit
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | NDUFS3 is the core subunit of the mitochondrial respiratory chain′s NADH dehydrogenase complex, also known as Complex I, the complex critical for the production of ATP and NADH electron transfer. In mammals Complex I consists of some 45 different proteins, NDUFS3 is the critical core subunit of the complex. Expressed in all cells and localized in the mitochondria but encoded by a nuclear gene, NDUFS3 plays a critical role in electron transport, our internal cellular respiratory chain, and mitochondrial function. NDUFS3 also is important in disease phenotypes and various cancers. Mutations in NDUFS3 give rise to Leigh syndrome a mitochondrial dysfunctional disease. In cancers, down regulation of NDUFS3 is linked with lowered host survival and increased cancer pathology. |
| Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to human NDUFS3. |
| Application【应用】 | This Anti-NDUFS3 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of NDUFS3. Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected NDUFS3 in human cerebral cortex, rat hippocampus, and rat cerebellum tissue. Research Category Neuroscience Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in THP-1 cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected NDUFS3 in 200 µg of THP-1 cell lysate. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 6H7.1, monoclonal |
| species reactivity | rat, human |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_004542 |
| UniProt accession no.【UniProt登记号】 | O75489 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~30 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
