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Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit
产品别名
Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit
Notch homolog 1
notch 1 (translocation-associated)
translocation-associated (Drosophila) (TAN1)
NOTC1
neurogenic locus notch 1
鍩烘湰淇℃伅
| NACRES | NA.41 |
| General description【涓�鑸弿杩啊� | The NOTCH1 gene is mapped to human chromosome 9q34 and encodes a member of the NOTCH family of proteins. The gene encodes a large transmembrane protein that contains an extracellular domain with 36 tandem epidermal growth factor (EGF)-like repeats and three cysteine-rich Notch/LIN-12 repeats, a six ankyrin repeat-containing intracellular domain, and a transactivation domain. Anti-NOTCH1 (Cleaved-Val1754) Antibody detects endogenous levels of fragment of activated NOTCH1 (Cleaved-Val1754) protein. |
| Immunogen【鍏嶇柅鍘煛� | The antiserum was produced against synthesized peptide derived from human Notch 1. Immunogen Range: 1735-1784 |
| Application【搴旂敤】 | Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit has been used in immunohistochemistry (IHC). |
| Biochem/physiol Actions【鐢熷寲/鐢熺悊浣滅敤】 | The Notch1 protein is a transmembrane receptor that induces pluripotent progenitor cells to form T-cells and facilitates the assembly of pre鈥揟 cell receptor complexes in immature thymocytes. It participates in an intracellular signaling pathway that regulates cellular differentiation, cell fate and lateral inhibition. Mutations in this gene have been associated with human blood cancers, abnormal cardiovascular calcification, aortic valve disease, and human T cell acute lymphoblastic leukemia. |
| Features and Benefits【鐗圭偣鍜屼紭鍔俊� | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【澶栧舰】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
浜у搧鎬ц川
| biological source【鐢熺墿鏉ユ簮】 | rabbit |
| Quality Level【璐ㄩ噺姘村钩】 | 100 |
| conjugate【鍋惰仈鐗� | unconjugated |
| antibody form【鎶椾綋褰㈠紡】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【鍏嬮殕】 | polyclonal |
| form【褰㈠紡】 | buffered aqueous solution |
| mol wt【鍒嗗瓙閲彙� | antigen 110 kDa |
| species reactivity | rat, human, mouse |
| concentration【娴撳害】 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI鐧昏鍙贰� | P46531 |
| UniProt accession no.【UniProt鐧昏鍙贰� | P46531 |
| application(s) | research pathology |
| shipped in【杩愯緭】 | wet ice |
| storage temp.【鍌ㄥ瓨娓╁害】 | −20鈩� |
| Gene Information | human ... NOTCH1(4851) |
浜у搧璇存槑
| Disclaimer【鍏嶈矗澹版槑】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
瀹夊叏淇℃伅
| Storage Class Code【鍌ㄥ瓨鍒嗙被浠ｇ爜】 | 12 - Non Combustible Liquids |
| WGK | nwg |
