您的位置：首页 > 产品中心 > Anti-Notch 1 Antibody, extracellular
Anti-Notch 1 Antibody, extracellular
| 产品编号： | 4111346 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 渭L |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Notch 1 Antibody, extracellular
Notch homolog 1, translocation-associated (Drosophila), Notch (Drosophila) homolog 1 (translocation-associated), Translocation-associated notch protein TAN-1, neurogenic locus notch homolog protein 1
鍩烘湰淇℃伅
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【涓�鑸弿杩啊� | The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch-1. notch-2, notch-3, and notch-4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of notch-1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm). |
| Specificity【鐗瑰紓鎬А� | This antibody recognizes Notch 1. |
| Immunogen【鍏嶇柅鍘煛� | GST-tagged recombinant protein corresponding to the extracellular domain of rat Notch 1. Epitope: Extracellular domain |
| Application【搴旂敤】 | Anti-Notch 1 Antibody, extracellular detects level of Notch 1 & has been published & validated for use in WB, IH(P). Research Sub Category Growth Factors & Receptors Research Category Signaling Immunohistochemistry Analysis: 1:400 dilution of this antibody has been shown to detect Notch 1 in gastrointestinal and colorectal carcinoma tissue. |
| Quality【璐ㄩ噺】 | Evaluated by Western Blot in human lymph node lysate. Western Blot Analysis: 1:500 dilution of this antibody detected Notch 1 on 10 µg of human lymph node lysate. |
| Physical form【澶栧舰】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. Affinity purified |
| Analysis Note【鍒嗘瀽璇存槑】 | Control Human lymph node lysate |
浜у搧鎬ц川
| biological source【鐢熺墿鏉ユ簮】 | rabbit |
| Quality Level【璐ㄩ噺姘村钩】 | 100 |
| antibody form【鎶椾綋褰㈠紡】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【鍏嬮殕】 | polyclonal |
| purified by【绾寲鏂瑰紡】 | affinity chromatography |
| species reactivity | human, rat |
| species reactivity (predicted by homology) | canine (91% sequence homology), mouse (97% sequence homology), chimpanzee (92% sequence homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI鐧昏鍙贰� | NP_001099191 |
| UniProt accession no.【UniProt鐧昏鍙贰� | Q07008 |
| shipped in【杩愯緭】 | wet ice |
浜у搧璇存槑
| Target description【鐩爣鎻忚堪】 | ~260 kDa observed. Notch 1, extracellular is calculated at ~183 kDa |
| Storage and Stability【鍌ㄥ瓨鍙婄ǔ瀹氭�А� | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【鍏嶈矗澹版槑】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
瀹夊叏淇℃伅
| Storage Class Code【鍌ㄥ瓨鍒嗙被浠ｇ爜】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
