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Anti-Noxa BH3 Domain antibody produced in rabbit
| 产品编号： | 4111375 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 100 渭G |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Noxa BH3 Domain antibody produced in rabbit
Anti-PMA-induced protein 1
Anti-Immediate-early-response protein APR
Anti-PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1
Anti-PMAIP1
鍩烘湰淇℃伅
| NACRES | NA.41 |
| General description【涓�鑸弿杩啊� | The expression of the Noxa gene, a BH3 only member of the Bcl2 family, involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53 deficient thymocytes. Co-immunoprecipitation data suggests that Noxa protein may interact with proteins belonging to the Bcl2 family, such as, BclXL and Mcl1. Blocking endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation induced apoptosis, suggesting that Noxa may mediate p53 dependent apoptosis. |
| Immunogen【鍏嶇柅鍘煛� | NOXA (NP_066950, 12-52) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region (BH3 domain) of human Noxa. |
| Physical form【澶栧舰】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
浜у搧鎬ц川
| biological source【鐢熺墿鏉ユ簮】 | rabbit |
| Quality Level【璐ㄩ噺姘村钩】 | 200 |
| conjugate【鍋惰仈鐗� | unconjugated |
| antibody form【鎶椾綋褰㈠紡】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【鍏嬮殕】 | polyclonal |
| form【褰㈠紡】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: 1:1000 |
| NCBI accession no.【NCBI鐧昏鍙贰� | NP_066950 |
| UniProt accession no.【UniProt鐧昏鍙贰� | Q13794 |
| shipped in【杩愯緭】 | dry ice |
| storage temp.【鍌ㄥ瓨娓╁害】 | −20鈩� |
| Gene Information | human ... NOXA(5366) |
瀹夊叏淇℃伅
| Storage Class Code【鍌ㄥ瓨鍒嗙被浠ｇ爜】 | 12 - Non Combustible Liquids |
| WGK | nwg |
