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Anti-Noxa BH3 Domain antibody produced in rabbit
| 产品编号： | 4111375 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Noxa BH3 Domain antibody produced in rabbit
Anti-PMA-induced protein 1
Anti-Immediate-early-response protein APR
Anti-PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1
Anti-PMAIP1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The expression of the Noxa gene, a BH3 only member of the Bcl2 family, involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53 deficient thymocytes. Co-immunoprecipitation data suggests that Noxa protein may interact with proteins belonging to the Bcl2 family, such as, BclXL and Mcl1. Blocking endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation induced apoptosis, suggesting that Noxa may mediate p53 dependent apoptosis. |
| Immunogen【免疫原】 | NOXA (NP_066950, 12-52) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region (BH3 domain) of human Noxa. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: 1:1000 |
| NCBI accession no.【NCBI登记号】 | NP_066950 |
| UniProt accession no.【UniProt登记号】 | Q13794 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... NOXA(5366) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
