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Anti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488
| 产品编号： | 4111766 |
| 规格： | clone 11F12.1, from mouse, ALEXA FLUOR® 488 |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488
Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, P40
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Tumor protein 63 (UniProt Q9H3D4; also known as Amplified in squamous cell carcinoma, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, p40, p51, p73L, TP63, Transformation-related protein 63, Tumor protein p73-like) is encoded by the TP63 (also known as KET, P63, P73H, P73L, TP73L) gene (Gene ID 8626) in human. Tumor protein 63 is a p53 homologue that can bind p53-responsive elements to upregulate some p53 target genes and share partially overlapping functions with p53. Various functions have been ascribed to TP63 in normal squamous epithelia, including those of the esophagus and TP63 is reported to play an essential role in the maintenance of proliferative potential in epithelial stem cells. TP63 overexpression is found in various squamous epithelia carcinomas and high TP63 expression is associated with an aggressive phenotype and metastasis in many cancers. |
| Specificity【特异性】 | Expected to react with spliced isoform 2 (DeltaN-alpha, DeltaNp63 alpha, P51delNalpha), 4 (DeltaN-beta, DeltaNp63 beta, P51delNbeta), 6 (DeltaN-gamma, DeltaNp63gamma, P51delNgamma), 8 (DeltaN-delta), 10 (DeltaN-epsilon, DeltaNp73L), 12, but not isoform 1 (TA*-alpha, TAp63alpha, P51B), 3 (TA*-beta, TAp63beta), 5 (TA*-gamma, TAp63gamma, P51A), 7 (TA*-delta, TAp63delta, P51delta), 9 (TA*-epsilon), or 11 (P63 delta). |
| Immunogen【免疫原】 | Epitope: Near N-terminus KLH-conjugated linear peptide corresponding to human P40 near the N-terminus. |
| Application【应用】 | Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected P40 in HUVEC cells. The unconjugated version (Cat. No. MABS519) has been shown to work in WB, IH(P). Research Category Signaling Research Sub Category Signaling Neuroscience This Alexa Fluor® 488 conjugated Anti-P40 Antibody, clone 11F12.1, is validated for use in Immunocytochemistry (IHC) for the detection of P-40. |
| Quality【质量】 | Evaluated by Immunocytochemistry in NIH/3T3 cells. Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected P40 in NIH/3T3 cells. |
| Physical form【外形】 | Protein G Purified Purified mouse conjugate antibody in PBS with 15 mg/ml BSA and 0.1 sodium azide. |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
| Legal Information【法律信息】 | ALEXA FLUOR is a registered trademark of Life Technologies |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | ALEXA FLUOR® 488 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 11F12.1, monoclonal |
| species reactivity | mouse, human |
| technique(s) | immunocytochemistry: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001108450 |
| UniProt accession no.【UniProt登记号】 | Q9H3D4 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~40 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
