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Anti-p38/SAPK2A Antibody
| 产品编号： | 4111780 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-p38/SAPK2A Antibody
Mitogen-activated protein kinase 11, MAP kinase 11, MAPK 11, Mitogen-activated protein kinase p38 beta, MAP kinase p38 beta, p38b, Stress-activated protein kinase 2, p38-2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The p38 family refers to the SAPK2/3 Kinases (Stress-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation. |
| Specificity【特异性】 | This antibody recognizes p38/SAPK2A at the protein kinase domain. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the protein kinase domain of human p38/SAPK2A. |
| Application【应用】 | This Anti-p38/SAPK2A Antibody is validated for use in WB for the detection of p38/SAPK2A. |
| Quality【质量】 | Evaluated by Western Blot in human brain tissue lysate. Western Blot Analysis: 0.1 µg/mL of this antibody detected p38/SAPK2A on 10 µg of human brain tissue lysate. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, rat, horse, mouse |
| species reactivity (predicted by homology) | rhesus macaque (based on 100% sequence homology), equine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_002742 |
| UniProt accession no.【UniProt登记号】 | Q15759 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~41 kDa observed. An uncharacterized band appears at ~35 kDa in some lysates. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
