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Anti-PCSK9 Antibody
| 产品编号： | 4111976 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PCSK9 Antibody
NARC-1, PC9, Subtilisin/kexin-like protease PC9, Proprotein convertase 9, Neural apoptosis-regulated convertase 1, Proprotein convertase subtilisin/kexin type 9
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | PCSK9 protein is an important protein in the regulation of plasma cholesterol homeostasis. PCSK9 binds various lipid receptor protein members including low density lipoprotein receptors (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2) and promotes their degradation or sequestration. In neurons, PCSK9 regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. PCSK9 is localized in cytoplasm but it is also secreted and thus can be found in endosomes, lysosomes, and endoplasmic reticulum and Golgi as well. PCSK9 is expressed in normal cells such as Schwann cells and pancreatic epithelial cells but PCSK9 is also expressed in many cancers and cancer cells lines as well. |
| Immunogen【免疫原】 | His-tagged recombinant protein corresponding to Human PCSK9. |
| Application【应用】 | This Anti-PCSK9 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of PCSK9. Research Sub Category Lipid Signaling Liver Physiology Research Category Signaling Metabolism Western Blotting Analysis: A representative lot of this antibody detected PCSK9 protein in treated HepG2 cell lysate (Jeong, H. J., et al. J. Lipid Res. 2008. 49: 399–409.) Western Blotting Analysis: A representative lot of this antibody detected PCSK9 protein in siRNA transfected HepG2 cells without and with BBR treatment (Data compliments of Sahng Wook Park of Yongsei University College of Medicine). |
| Quality【质量】 | Evaluated by Immunocytochemistry on HepG2 cells Immunocytochemistry Analysis: 8.0 µg/mL of this antibody detected PCSK9 in HepG2 cells. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide with 30% glycerol. Antigen Affinity Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_777596 |
| UniProt accession no.【UniProt登记号】 | Q8NBP7 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~75 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
