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Anti-phospho MEKK5, (Thr845), clone PA214 Antibody
产品别名
Anti-phospho MEKK5, (Thr845), clone PA214 Antibody
MEKK5, Apoptosis signal-regulating kinase 1, MAPK/ERK kinase kinase 5, ASK-1, MEK kinase 5, MEKK 5, ASK1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | MEKK5 (MAP3K5) is a key kinase for our innate immunity and for mediating cellular signaling cascades evoked by changes in the external cellular environment. As such, MEKK5 is critical for cell fate during development, apoptosis, and cell survival as well as in modulating the host defense responses from a wide range of pathogens. MEKK5 acts as an upstream activator of the MKK/JNK signaling pathways and the p38 MAPK signaling pathways that ultimately results in activating multiple kinases such as MAP2K3/Mkk3 or MKK6/MMK7. Activation of MMEKK5 is via phosphorylation of Thr-845 within the activation loop via the recently discovered kinase MAP3K6 which forms a complex with MEKK5 and also stabilizes the protein. Expression is widespread and localized in the cytoplasmic in the perinuclear endoplasmic reticulum region. |
| Immunogen【免疫原】 | linear peptide corresponding to Human phospho MEKK5 (Thr 845). |
| Application【应用】 | Anti-phospho MEKK5, (Thr845), clone PA214 | MABS494 is an antibody against phospho MEKK5 for use in Western Blotting. Research Category Signaling Research Sub Category Immunological Signaling |
| Quality【质量】 | Evaluated by Western Blotting on HEK293A lysate Western Blotting Analysis: 4 µg/mL dilution of this antibody detected phosphorylated MEKK5 protein in 10 µg of H2O2 treated Hek293A cell lysate |
| Physical form【外形】 | Format: Purified Purified rabbit monoclonal supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Protein G Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | PA214, monoclonal |
| species reactivity | mouse, human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_005914 |
| UniProt accession no.【UniProt登记号】 | Q99683 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~160 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
