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Anti-Phospho-AMPKβ1-S108 antibody produced in rabbit
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | liquid |
| species reactivity | mouse, rat, human |
| concentration【浓度】 | 0.74 mg/mL |
| technique(s) | immunohistochemistry: 1:50-1:100 immunohistochemistry: 1:50-1:200 western blot: 1:2000-1:5000 |
| UniProt accession no.【UniProt登记号】 | Q9Y478 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PRKAB1(5564) |
基本信息
| General description【一般描述】 | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. |
| Immunogen【免疫原】 | A synthetic phosphorylated peptide around S108 of human AMPKβ1 (NP_006244.2). |
| Physical form【外形】 | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
