Anti-Phospho-ERBB2-Y1248 antibody produced in rabbit

rabbit

100

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

134
136
137
62
70
97

human

0.71 mg/ml

western blot: 1:500-1:2000

P04626

wet ice

−20℃

human ... ERBB2(2064)

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

A synthetic phosphorylated peptide around Y1248 of human ERBB2 (NP_004439.2).

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

12 - Non Combustible Liquids

WGK 1