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产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | liquid |
| species reactivity | human, rat |
| concentration【浓度】 | 1.41 mg/mL |
| technique(s) | immunohistochemistry: 1:50-1:200 western blot: 1:500-1:2000 |
| UniProt accession no.【UniProt登记号】 | P04637 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TP53(7157) |
基本信息
| General description【一般描述】 | This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). |
| Immunogen【免疫原】 | A synthetic phosphorylated peptide around S15 of human p53 (NP_000537.3). |
| Physical form【外形】 | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
