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Anti-PIDD Antibody, clone 1511.1
产品别名
Anti-PIDD Antibody, clone 1511.1
p53-induced protein with a death domain, Leucine-rich repeat and death domain-containing protein, PIDD
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | p53-induced protein with a death domain (PIDD) is also called Leucine-rich repeat and death domain-containing protein (LRDD). PIDD is involved in apoptosis downstream of the tumor suppressor. PIDD is a component of the DNA damage/stress response pathway in which p53/TP53 is associated with apoptosis. PIDD also aids in the activation of the transcription factor NF-kappa-B, and CASP2 which regulates apoptotic pathways. |
| Specificity【特异性】 | This antibody demonstrates specificity for isoform 4, but may detect isoform 1, 2 and 3. It will not detect isoforms 5, 6, and 7 based upon immunogen design. |
| Immunogen【免疫原】 | Recombinant protein corresponding to human PIDD. |
| Application【应用】 | Western Blotting Analysis: 1 µg/mL from a representative lot detected PIDD in 10 µg of NIH/3T3 and PC-12 cell lysate. Immunohistochemistry Analysis: A 1:100 dilution, a 1:500 dilution, and a 1:1,000 dilution detected PIDD in HeLa, A431, and NIH/3T3 cells. Anti-PIDD Antibody, clone 1511.1 is a highly specific mouse monoclonal antibody, that targets p53-induced protein with a death domain & has been tested in western blotting & ICC. |
| Quality【质量】 | Evaluated by Western Blotting in HeLa cell lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected PIDD in 10 µg of HeLa cell lysate. |
| Physical form【外形】 | Purified mouse IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Protein G Purified Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 15F11.1, monoclonal |
| species reactivity | rat, mouse, human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_665893 |
| UniProt accession no.【UniProt登记号】 | Q9HB75 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~66 kDa observed. Uniprot describes 7 different isoforms. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
