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Anti-PITX3 Antibody, clone 12G4.1
产品别名
Anti-PITX3 Antibody, clone 12G4.1
Pituitary homeobox 3, Homeobox protein PITX3, Paired-like homeodomain transcription factor 3
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Pituitary homeobox 3 (UniProt O75364; also known as Homeobox protein PITX3, Paired-like homeodomain transcription factor 3) is encoded by the PITX3 (also known as ASMD, CTPP4, CTRCT11, PTX3) gene (Gene ID 5309) in human. PITX3 is a bicoid-related homeodomain transcription factor critical for the development of the ocular lens, mesencephalic dopaminergic neurons and skeletal muscle. PITX3 exerts its developmental impact on dopaminergic neurons by directly regulating the expression of a cascade of downstream genes, including TH, VMAT2, DAT, BDNF, and GDNF. PITX3 and the related PITX2 are both key regulators of intracellular redox state and play an important role in preventing DNA damage during fetal myogenesis. Human PITX3 gene mutations are linked to cataracts and anterior segment abnormalities and PITX3 polymorphisms are associated with Parkinson′s disease. In aphakia (ak) mice, deletions in the Pitx3 promoter region cause abnormal lens development. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to a sequence within the N-terminal region of human PITX3. |
| Application【应用】 | Anti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting. |
| Quality【质量】 | Evaluated by Western Blotting in human retinoblastoma Y79 cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected PITX3 in 10 µg of human retinoblastoma Y79 cell lysate. |
| Physical form【外形】 | Protein G Purified Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 12G4.1, monoclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG2aκ |
| NCBI accession no.【NCBI登记号】 | NP_005020 |
| UniProt accession no.【UniProt登记号】 | O75364 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... PITX3(5309) |
产品说明
| Target description【目标描述】 | ~32 kDa observed. Uncharacterized band(s) may appear in some lysates. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
