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Anti-PTRF/Cavin-1 Antibody
| 产品编号： | 4113321 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PTRF/Cavin-1 Antibody
Polymerase I and transcript release factor, Cavin-1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Polymerase I and transcript release factor (PTRF), also known as “cavin-1,” is a small cytoplasmic protein, which interacts with caveolin-1 to assemble specialized membrane invaginations (or caveolae), in various types of cells. Caveolae house specific proteins and lipids and play a central role in cell signaling and endocytosis. PTRF may also play a role in metabolism. Mice lacking functional PTRF are affected by hyperinsulinemia and glucose intolerance. In addition, PTRF may play a role in prostate cancer. |
| Specificity【特异性】 | This antibody recognizes the Coiled Coil domain of PTRF/cavin-1. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the Coiled Coil domain of human PTRF/cavin-1. |
| Application【应用】 | Anti-PTRF/cavin-1 Antibody detects level of PTRF/cavin-1 & has been published & validated for use in Western Blotting, IHC(P). Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected PTRF/cavin-1 in mouse cardiac tissue and mouse alveoli tissue. |
| Quality【质量】 | Evaluated by Western Blot in human lung tissue lysate. Western Blot Analysis: 1 mg/mL of this antibody detected PTRF/cavin-1 in 10 mg of human lung tissue lysate. |
| Other Notes【其他说明】 | Protein A purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human, rat |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_036364 |
| UniProt accession no.【UniProt登记号】 | Q6NZI2 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~60 kDa, ~43 kDa observed. Three isoforms at 43 kDa, 33 kDa, and 23 kDa are known to exist. This protein was observed at ~60 kDa by an independent laboratory due to post-translational modification (Hill, M. M., et al. (2008). Cell. 132(1):113-124.). |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
