您的位置：首页 > 产品中心 > Anti-RGS11 (CT) Antibody
产品别名
Anti-RGS11 (CT) Antibody
Regulator of G-protein signaling 11, RGS11
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Regulator of G-protein signaling 11 (RGS11) is a multidomain GTPase containing one each of DEP, RGS, and G-protein gamma domains. Like other members of the R7 RGS family, RGS11 uses these domains to form multisubunit complexes, which process the light responses of retinal cells. RGS11 interacts with the RGS9 anchor protein (R9AP) and the 5 G-protein beta subunit (Gbeta5) to form a trimeric complex that regulates the activity of the metabotropic glutamate receptor 6 (mGluR6) in ON-bipolar cells. The RGS11 complex hydrolyzes GTP and inactivates the G-protein Galphao, which is activated by mGluR6 in dark environments. By this mechanism, the RGS11 complex accelerates the light response in ON-bipolar retinal cells. |
| Specificity【特异性】 | This antibody recognizes the C-terminus of RGS11. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the C-terminus of human RGS11. Epitope: C-terminus |
| Application【应用】 | Research Sub Category GPCR, cAMP/cGMP & Calcium Signaling Detect RGS11 (C-terminus) using this Anti-RGS11 (C-terminus) Antibody validated for use in Western Blotting. Research Category Neuroscience |
| Quality【质量】 | Evaluated by Western Blot in human placenta tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected RGS11 in 10 µg of human placenta tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Affinity purified |
| Analysis Note【分析说明】 | Control Human placenta tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 300 |
| biological source【生物来源】 | rabbit |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | rat, human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003825 |
| UniProt accession no.【UniProt登记号】 | O94810 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~53 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
